Schematic Industries are specialists at manufacturing bespoke, client specific Barrier Isolator systems to cGMP and cGAMP standards. We manufacture both Rigid and Flexible barrier isolator systems with a negative pressurised internal environment and Rigid isolators with positive pressurised internal environments.

Our negative (-ve) barrier isolators are essential where the process media is hazardous, dangerous or has an unacceptably high toxic level.

These barrier isolator systems operate under a light vacuum (100 Pa) to provide an uncompromising and continuous isolation of the interior from the external environment. This also provides a risk-free environment for the operator as potent vapours are taken to the systems filtered exhaust rather towards to operator. Typical barrier isolator applications in both API and Formulation sectors include;

API Isolators Duties

  • Dispensing & Sampling Isolators
  • Reactor Charging Isolator
  • ANFD Discharge Isolator
  • Centrifuge & Distillation Isolators
  • Filtration & Drying Isolators

Formulation Isolator Duties

  • Granulation Isolator
  • QC Isolator
  • Milling & Blending Isolator
  • Pack off Isolator
  • Sieving & Weighing Isolators

Design Features

Design Features

  • Rugged 316 Stainless Steel build with fully welded, large radius and polished corners
  • Push-push type safe changeable HEPA filters on inlet and outlet vents
  • cGAMP - PLC/HMI controlled - Digital pressure controller or Electrical controller to maintain a constant pressure
  • Integrated Clean In Place / washable to reach every corner of chamber
  • Integrated Weighing Scale, Nutsche Filter, Vacuum Tray Dryer, Continuous liner port and Drum loader
  • Laminar airflow
  • Oxygen monitoring / Nitrogen inertization
  • Complete Documentation – FDS, DQ, FAT, IQ, OQ, OMM, Leak test, Lux, Noise, Air change, Filter integrity, Glove test and OEL
  • Integration with RTP for safe and rapid transfer
  • Split Butterfly valve for safe transfer of material
  • Multiple or Single Chambers
  • Isolator raise/lower systems for operator comfort